There is no doubt that the pain is unbearable, but the question is, is there any medication? So, yes, there are some medicines that a girl can take before or during menstruation. Although there are so many brands of period pain medication, some of them are Naproxen, ibuprofen, mefenamic acid, Aleve, Cataflam, and many more. But in general, it has been noticed that taking medicines can be dangerous in most cases. Also, it can make you hospitalized. So if you are taking any drug to get relief from the period, before using it, talk to any gynecologist once.